Mechanisms of technology transfer as elements of the strengthening of accumulated knowledge in the Mexican biopharmaceutical industry: The Case of the UDIBI - IPN

Ana Lilia Sánchez Regla, Alexandra Lizeth Ortiz Guzmán, María del Pilar Monserrat Pérez Hernández, Igor Rivera, Sonia Mayra Pérez Tapia


Introduction: The literature related to technology transfer (TT), has placed greater emphasis on organizations once they have established a collaborative link with higher education institutions (HEIs); however, there is little knowledge to observe the inverse effect, that is, the TT within an HEI after this interaction. This work deals with the case of a research and development laboratory (R & D) integrated to a federal public university, which, in addition to generating basic science for internal projects, offers technological services to the national and international biopharmaceutical sector; whose income allows them to self-finance their operation, using marginally the federal budget. Under an organizational and institutional approach, this article aims to publicize the mechanisms of TT that come together in this laboratory, but also, expose the contribution of these to the strengthening of their accumulated knowledge.

Method: This study was conducted from twenty-eight semi-structured interviews with personnel and external agents of the UDIBI, using differentiated questionnaires with open questions, and others, closed with Likert scales. Likewise, different collaboration agreements between this laboratory and other industry players were reviewed in order to observe the purpose of their interrelation. The processing of the information was done using the NVIVO software, which favored a more efficient analysis.

Results: The institutional laboratory studied requires the gathering of latest generation knowledge to develop its critical operation based on the generation of basic science and the offer of technological services. It was found that multiple and varied TT mechanisms (organizational and institutional) converge within this polytechnic entity, whose products are translated into knowledge of diverse nature that complements and enhances the accumulated base of our own knowledge and is the basis for the exploitation of scientific products. , technological and services of high value for both academia and industry. Another finding identified was that not only do these mechanisms transfer technology in only one direction; rather, given the contribution that this laboratory makes to its source of knowledge, the flow becomes bidirectional.

Discussion or Conclusion: The different mechanisms presented here are the product of the dynamics of the interaction that the laboratory studied with external and internal actors, where the assimilated knowledge of these, together with the own knowledge; but at the same time of a scientific-commercial vision on the part of its directive. All together, they form an important base of their current development, expansion, and even self-sustainability; representing, thus, one of the few cases of exception in Mexico, of similar scientific units integrated to public HEIs that aspire to transcend towards an enterprising approach of the universities.


technology transfer; technology transfer mechanisms; biotechnology; biopharmaceutical industry


Argote, L. I. (2000). Knowledge transfer in organizations: Learning from the experience of others. Organizational behavior and human decision processes, 82(1), 1-8.

Argote, L., & Ingram, P. (2000). Knowledge transfer: A basis for competitive advantage in firms. Organizational behavior and human decision processes, 82(1), 150-169.

Arora, A., Fosfuri, A., & Gambardella, A. (2004). A.Markets for technology: The economics of innovation and corporate strategy. MIT press.

Audretsch, D. B. (2001). The role of small firms in US biotechnology clusters. Small Business Economics, 17((1-2)), 3-15.

Audretsch, D., & Feldman, M. (2003). Small-firm strategic research partnerships: The case of biotechnology. 15(2),. Technology analysis & strategic management, 2, 273-288.

Bayona Sáez, C., García-Marco, T., & HUERTA ARRIBAS, E. (2003). ¿ Cooperar en I+ D? Con quién y para qué. Revista de Economía Aplicada, 11(31).

Berbegal-Mirabent, J., Alegre, I., & Guerrero, A. (2017). University Research Parks and their impact on technology transfer activities. Technological Innovation Networks: Collaboration and Partnership (Vol. 167).

Bercovitz, J., & Feldman, M. (2006). Entpreprenerial universities and technology transfer: A conceptual framework for understanding knowledge-based economic development. The Journal of Technology Transfer, 31(1).

Bianchi, M., & et al. (2011). Organisational modes for Open Innovation in the bio-pharmaceutical industry: An exploratory analysis,. Technovation, 31(1), 22-33.

Bozeman, B. (2000). Technology transfer and public policy: a review of research and theory. Research Policy, 627–655.

Bozeman, B., & et al. (2015). The evolving state-of-the-art in technology transfer research: Revisiting the contingent effectiveness model. Research Policy, 44(1), 34-49.

Chesbrough, H., & Crowther, A. (2006). Beyond high tech: early adopters of open innovation in other industries. R&D Management, 36(3), 229-236.

Cohen, W., & Levin, R. (1989). Empirical studies of innovation and market structure. Handbook of industrial organization, 2, 1059-1107.

Cohen, W., & Levinthal, D. (1990). Absorptive capacity: A new perspective on learning and innovation. Strategic Learning in a Knowledge economy, 39-67.

Cohen, W., Nelson, R., & Walsh, J. (2002). Links and impacts: the influence of public research on industrial R&D. Management science, 48(1), 1-23.

D’Este, P., & Patel, P. (2007). University–industry linkages in the UK: What are the factors underlying the variety of interactions with industry? Research policy, 36(9), 1295-1313.

Debackere, K., & Veugelers, R. (2005). The role of academic technology transfer organizations in improving industry science links. Research policy, 34,(3), 321-342.

Diario Oficial de la Federación . (2014). NORMA Oficial Mexicana NOM-257-SSA1-2014 en materia de medicamentos biotecnológicos.

Dubickis, M., & Gaile-Sarkane, E. (2015). Perspectives on Innovation and Technology Transfer. Procedia-Social and Behavioral Science, 213, 965-970.

Eisenhardt, K., & Martin, J. (2000). Dynamic capabilities: what are they? Strategic management journal, 21(10-11), 1105-1121.

Etzkowitz, H. (2003). Innovation in innovation: The triple helix of university-industry-government relations. Social science information, 42(3), 293-337.

Etzkowitz, H. (2003). Research groups as ‘quasi-firms’: the invention of the entrepreneurial university. Research Policy, 32, 109–121.

Etzkowitz, H., & et al. (2000). The future of the university and the university of the future: evolution of ivory tower to entrepreneurial paradigm. Research policy, 29(2), 313-330.

Etzkowitz, H., & Leydesdorff, L. (2000). The dynamics of innovation: from National Systems and “Mode 2” to a Triple Helix of university–industry–government relations. Research policy, 2, 109-123.

Etzkowitz, H., & Leydesdorff,, L. (2000). The dynamics of innovation: from National Systems and “Mode 2” to a Triple Helix of university–industry–government relations. Research policy, 29(2), 109-123.

Fukugawa, N. (2016). Knowledge spillover from university research before the national innovation system reform in Japan: localisation, mechanisms, and intermediaries. Asian Journal of Technology Innovation, 24(1), 100-122.

Günsel, A. (2015). Research on effectiveness of technology transfer from a knowledge based perspective. Procedia-Social and Behavioral Sciences, 777-785.

Guzman, A. (2014). Propiedad intelectual y capacidades de innovación en la industria farmacéutica de Argentina, Brasil y México. Mexico: UAM-Gedisa editorial .

Heller, M., & y Eisenberg, R. (1998). Can patents deter innovation? The anticommons in biomedical research. Science,, 698-701.

Hess, S., & Siegwart, R. (2013 ). R&D Venture: proposition of a technology transfer concept for breakthrough technologies with R&D cooperation: A case study in the energy sector. 38(2),. The Journal of Technology Transfer, 153-179.

Hu, A., Jefferson, G., & Jinchang, Q. (2005). R&D and technology transfer: firm-level evidence from Chinese industry. ,. Review of Economics and Statistics, 87(4), 780-786.

IPN. (n.d.). UPDCE . Retrieved from

Lema, A., & Lema, R. (2013). Technology transfer in the clean development mechanism: Insights from wind power. Global Environmental Change, 23(1), 301-313.

Levin, R., Klevorick, A., Nelson, R., & Winter, S. (1987). Appropriating the returns from industrial research and development. Brookings papers on economic activity, 3, 783-831.

Levitt, B., & March, J. (1988). Organizational learning. Annual Review of Sociology,, 14, 319–340.

Lichtenthaler, U., & Lichtenthaler, E. (2010). Technology transfer across organizational boundaries: absorptive capacity and desorptive capacity. California Management Review, 53(1), 154-170.

Mowery, D., & Oxley, J. (1995). Inward technology transfer and competitiveness: the role of national innovation systems. Cambridge journal of economics, 19(1), 67-93.

Nelson, R., & Winter, S. (1982). An evolutionary theory of economic change.

Ortiz, A. (2016). Capacidades Tecnológicas y de vinculación: Unidad de Desarrollo e Investigación en Bioprocesos para servicios la industria biofarmacéutica. Tesis de Maestria, Instituto Politécnico Nacional.

Pérez, P. (2014). Organizaciones intermedias en la actividad innovadora: el caso de México. . México: Instituto Politécnico Nacional.

Perkmann, M., & Walsh, K. (2007). University–industry relationships and open innovation: Towards a research agenda. International Journal of Management Reviews, 9(4), 259-280.

Powell, W. (1998). Learning from collaboration: Knowledge and networks in the biotechnology and pharmaceutical industries. California management review, 40(3), 228-240.

Ramadhan, F. S. (2017). Mechanisms for effective tacit knowledge transfer in university laboratory: An agent-based approach. . In 2017 IEEE International Conference on Industrial Engineering and Engineering Management (IEEM), (pp. 1138-1142).

Reisman, A. (2005). Transfer of technologies: a cross-disciplinary taxonomy. Omega, 33 (3), 189-202.

Rothaermel,, F. (2001). Complementary assets, strategic alliances, and the incumbent’s advantage: an empirical study of industry and firm effects in the biopharmaceutical industry. Research policy, 30(8), 1235-1251.

Schumpeter, A. ((1943) 2010). Capitalism, socialism and democracy. Routledge.

Szulanski, G. (1996). Exploring internal stickiness: Impediments to the transfer of best practice within the firm.,. Strategic management journal, 17(S2), 27-43.

Teece, D. (1975). Multinational corporation and the resource cost of international technology transfer. Pennsylvania: University of Pennsylvania.

Teece, D. (1977). Technology transfer by multinational firms: the resoursce cost of transfering Techological know-how. The Economic Journal, 242-261.

Teece, D., & et al. (1997). Dynamic capabilities and strategic management. Strategic management journal, 18(7), 509-533.

Tsai, W. (2001). Knowledge transfer in intraorganizational networks: Effects of network position and absorptive capacity on business unit innovation and performance. Academy of management journal, 44(5), 996-1004.

UDIMEB-IPN. (n.d.). Retrieved from

Yin, R. (1994). Case study research and applications: Design and methods. . Sage publications.

Yoo, S., Sawyer, O., & Tan, W. (2015). The impact of exogenous and endogenous factors on external knowledge sourcing for innovation: The dual effects of the external environment. The Journal of High Technology Management Research, 26(1), 14-26.



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